Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks.

ABSTRACT:

Purpose

Genomic complexity is present in approximately 15% to 30% of all chronic lymphocytic leukemia (CLL) and has emerged as a strong independent predictor of rapid disease progression and short remission duration in CLL. We conducted this study to advance our understanding of the causes of genomic complexity in CLL.

Experimental design

We have obtained quantitative measurements of radiation-induced apoptosis and radiation-induced ATM autophosphorylation in purified CLL cells from 158 and 140 patients, respectively, and have used multivariate analysis to identify independent contributions of various biological variables on genomic complexity in CLL.

Results

Here, we identify a strong independent effect of radiation resistance on elevated genomic complexity in CLL an

SUBMITTER: Ouillette P 

PROVIDER: S-EPMC2818663 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature