Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.

ABSTRACT: A series of thiadiazole derivatives has been designed as potential allosteric, substrate competitive inhibitors of the protein kinase JNK. We report on the synthesis, characterization and evaluation of a series of compounds that resulted in the identification of potent and selective JNK inhibitors targeting its JIP-1 docking site.

SUBMITTER: De SK 

PROVIDER: S-EPMC2818674 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature