Corazonin neurons function in sexually dimorphic circuitry that shape behavioral responses to stress in Drosophila.

ABSTRACT: All organisms are confronted with dynamic environmental changes that challenge homeostasis, which is the operational definition of stress. Stress produces adaptive behavioral and physiological responses, which, in the Metazoa, are mediated through the actions of various hormones. Based on its associated phenotypes and its expression profiles, a candidate stress hormone in Drosophila is the corazonin neuropeptide. We evaluated the potential roles of corazonin in mediating stress-related changes in target behaviors and physiologies through genetic alteration of corazonin neuronal excitability. Ablation of corazonin neurons confers resistance to metabolic, osmotic, and oxidative stress, as measured by survival. Silencing and activation of corazonin neurons lead to differential lifespan under

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC2818717 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature