Lipoprotein particle subclasses, cardiovascular disease and HIV infection.

ABSTRACT:

Objective

To study the association of lipoprotein particles with CVD in a subgroup of HIV-infected patients who were enrolled in the Strategies for Management of Anti-Retroviral Therapy (SMART) study. SMART was a trial of intermittent use of ART (drug conservation [DC]) versus continuous of ART (viral suppression [VS]).

Methods

In a nested case-control study, lipoprotein particles (p) by nuclear magnetic resonance were measured at baseline and at the visit prior to the CVD event (latest levels) for 248 patients who had a CVD event and for 480 matched controls. Odds ratios (ORs) were estimated using conditional logistic models.

Results

Total, large and small HDL-p, but not VLDL-p nor LDL-p, were significantly and inversely associated with CVD and its major component, n

SUBMITTER: Duprez DA 

PROVIDER: S-EPMC2818719 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature