Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community.

ABSTRACT:

Background

Plasma high-density lipoprotein cholesterol concentration is related inversely to the risk of cardiovascular disease (CVD). Inhibiting cholesteryl ester transfer protein (CETP) activity raises high-density lipoprotein cholesterol and may be cardioprotective, but an initial clinical trial with a CETP inhibitor was stopped prematurely because of increased CVD in treated patients, raising concerns about this approach. Data relating circulating CETP concentrations to CVD incidence in the community are conflicting.

Methods and results

Plasma CETP activity was measured in 1978 Framingham Heart Study participants (mean age, 51 years; 54% women) who attended a routine examination in 1987-1990 and were free of CVD. On follow-up (mean, 15.1 years), 320 participants experien

SUBMITTER: Vasan RS 

PROVIDER: S-EPMC2818786 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature