Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice.

ABSTRACT:

Rationale

Lamina-associated polypeptide (LAP)2alpha is a mammalian chromatin-binding protein that interacts with a fraction of A-type lamins in the nuclear interior. Because mutations in lamins and LAP2alpha lead to cardiac disorders in humans, we hypothesized that these factors may play important roles in heart development and adult tissue homeostasis.

Objective

We asked whether the presence of LAP2alpha was required for normal cardiac function.

Methods and results

To study the molecular mechanisms of the disease, we analyzed heart structure and function in complete and conditional Lap2alpha(-/-) mice as well as Lap2alpha(-/-)/Mdx mutants. Unlike conditional deletion of LAP2alpha in late embryonic striated muscle, its complete knockout caused systolic dysfunction in

SUBMITTER: Gotic I 

PROVIDER: S-EPMC2818815 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature