Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs.
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ABSTRACT:
SUBMITTER: Kim DH
PROVIDER: S-EPMC2818944 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
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Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs.
Kim Deok-Ho DH Lipke Elizabeth A EA Kim Pilnam P Cheong Raymond R Thompson Susan S Delannoy Michael M Suh Kahp-Yang KY Tung Leslie L Levchenko Andre A
Proceedings of the National Academy of Sciences of the United States of America 20091216 2
Heart tissue possesses complex structural organization on multiple scales, from macro- to nano-, but nanoscale control of cardiac function has not been extensively analyzed. Inspired by ultrastructural analysis of the native tissue, we constructed a scalable, nanotopographically controlled model of myocardium mimicking the in vivo ventricular organization. Guided by nanoscale mechanical cues provided by the underlying hydrogel, the tissue constructs displayed anisotropic action potential propaga ...[more]
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