Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function.

ABSTRACT:

Objectives

The objective of this prospective, single-site, 2-year dietary intervention study was to evaluate the effects of moderate weight reduction and subsequent partial weight regain on cardiovascular structure and function.

Background

Obesity is associated with adverse cardiac and vascular structural and functional alterations.

Methods

Sixty obese subjects (age 46 + or - 10 years, body mass index 37 + or - 3 kg/m(2)) were evaluated during their participation in a weight loss study. Cardiac and vascular ultrasound studies were performed at baseline and at 3, 6, 12, and 24 months after start of intervention.

Results

Forty-seven subjects (78%) completed the entire 2-year follow-up. Average weight loss was 7.3 + or - 4.0%, 9.2 + or - 5.6%, 7.8 + or - 6.6%, and

SUBMITTER: de las Fuentes L 

PROVIDER: S-EPMC2818984 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature