Valence tautomerism in titanium enolates: catalytic radical haloalkylation and application in the total synthesis of neodysidenin.

ABSTRACT: A direct ruthenium-catalyzed radical chloroalkylation of N-acyl oxazolidinones capitalizing on valence tautomerism of titanium enolates has been developed. The chloroalkylation method served as the centerpiece in the enantioselective total synthesis of trichloroleucine-derived marine natural product neodysidenin.

SUBMITTER: Beaumont S 

PROVIDER: S-EPMC2819066 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature