The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis.

ABSTRACT:

Background

The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of derivatives. A number of proteins involved in neural crest development have dynamic expression patterns, and it is becoming clear that ubiquitin-mediated protein degradation is partly responsible for this.

Results

Here we demonstrate a novel role for the F-box protein Cdc4/Fbxw7 in neural crest development. Two isoforms of Xenopus laevis Cdc4 were identified, and designated xCdc4alpha and xCdc4beta. These are highly conserved with vertebrate Cdc4 orthologs, and the Xenopus proteins are functionally equivalent in terms of their ability to degrade Cyclin E, an esta

SUBMITTER: Almeida AD 

PROVIDER: S-EPMC2819241 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature