Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.

ABSTRACT: The dual bromodomain protein Brd2 is closely related to the basal transcription factor TAF(II)250, which is essential for cyclin A transactivation and mammalian cell cycle progression. In transgenic mice, constitutive lymphoid expression of Brd2 causes a malignancy most similar to human diffuse large B cell lymphoma. We compare the genome-wide transcriptional expression profiles of these lymphomas with those of proliferating and resting normal B cells. Transgenic tumors reproducibly show differential expression of a large number of genes important for cell cycle control and lymphocyte biology; expression patterns are either tumor-specific or proliferation-specific. Several of their human orthologs have been implicated in human lymphomagenesis. Others correlate with human disease survival t

SUBMITTER: Lenburg ME 

PROVIDER: S-EPMC2819333 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature