Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.

ABSTRACT: Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue

SUBMITTER: Langenhan T 

PROVIDER: S-EPMC2819344 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature