Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry.

ABSTRACT:

Background

Mpdz gene variations are known contributors of acute alcohol withdrawal severity and seizures in mice.

Methods

To investigate the relevance of these findings for human alcoholism, we resequenced 46 exons, exon-intron boundaries, and 2 kilobases in the 5' region of the human MPDZ gene in 61 subjects with a history of alcohol withdrawal seizures (AWS), 59 subjects with a history of alcohol withdrawal without AWS, and 64 Coriell samples from self-reported nonalcoholic subjects [all European American (EA) ancestry] and compared with the Mpdz sequences of 3 mouse strains with different propensity to AWS. To explore potential associations of the human MPDZ gene with alcoholism and AWS, single SNP and haplotype analyses were performed using 13 common variants.

Results

SUBMITTER: Karpyak VM 

PROVIDER: S-EPMC2819379 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature