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Plasma levels of S100A4 in portopulmonary hypertension.

ABSTRACT: We previously showed that a single nucleotide polymorphism in S100A4 was associated with portopulmonary hypertension (PPHTN) in patients with advanced liver disease. We aimed to determine the association between plasma levels of S100A4 and PPHTN. We performed a case-control study of patients with advanced liver disease. Cases with PPHTN had mean pulmonary artery pressure >25 mmHg, pulmonary vascular resistance >240 dynes s cm(-5) and pulmonary capillary wedge pressure

SUBMITTER: Peng T 

PROVIDER: S-EPMC2819481 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Plasma levels of S100A4 in portopulmonary hypertension.

Peng Tien T   Zamanian Roham R   Krowka Michael J MJ   Benza Raymond L RL   Roberts Kari E KE   Taichman Darren B DB   Rybak Debbie D   Trotter James F JF   Brown Robert S RS   Fallon Michael B MB   Kawut Steven M SM  

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20090501 3

We previously showed that a single nucleotide polymorphism in S100A4 was associated with portopulmonary hypertension (PPHTN) in patients with advanced liver disease. We aimed to determine the association between plasma levels of S100A4 and PPHTN. We performed a case-control study of patients with advanced liver disease. Cases with PPHTN had mean pulmonary artery pressure >25 mmHg, pulmonary vascular resistance >240 dynes s cm(-5) and pulmonary capillary wedge pressure </=15 mmHg. Controls with l  ...[more]