Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.

ABSTRACT:

Unlabelled

Organic solute transporter alpha-beta (Ostalpha-Ostbeta) is a heteromeric bile acid and sterol transporter that facilitates the enterohepatic and renal-hepatic circulation of bile acids. Hepatic expression of this basolateral membrane protein is increased in cholestasis, presumably to facilitate removal of toxic bile acids from the liver. In this study, we show that the cholestatic phenotype induced by common bile duct ligation (BDL) is reduced in mice genetically deficient in Ostalpha. Although Ostalpha(-/-) mice have a smaller bile acid pool size, which could explain lower serum and hepatic levels of bile acids after BDL, gallbladder bilirubin and urinary bile acid concentrations were significantly greater in Ostalpha(-/-) BDL mice, suggesting additional alternative ad

SUBMITTER: Soroka CJ 

PROVIDER: S-EPMC2819820 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature