Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice.

ABSTRACT:

Background

The 2009 influenza pandemic and shortages in vaccine supplies worldwide underscore the need for new approaches to develop more effective vaccines.

Methodology/principal findings

We generated influenza virus-like particles (VLPs) containing proteins derived from the A/California/04/2009 virus, and tested their efficacy as a vaccine in mice. A single intramuscular vaccination with VLPs provided complete protection against lethal challenge with the A/California/04/2009 virus and partial protection against A/PR/8/1934 virus, an antigenically distant human isolate. VLP vaccination induced predominant IgG2a antibody responses, high hemagglutination inhibition (HAI) titers, and recall IgG and IgA antibody responses. HAI titers after VLP vaccination were equivalent to tho

SUBMITTER: Quan FS 

PROVIDER: S-EPMC2820088 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature