Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae.

ABSTRACT:

Background

Biofuels offer a viable alternative to petroleum-based fuel. However, current methods are not sufficient and the technology required in order to use lignocellulosic biomass as a fermentation substrate faces several challenges. One challenge is the need for a robust fermentative microorganism that can tolerate the inhibitors present during lignocellulosic fermentation. These inhibitors include the furan aldehyde, furfural, which is released as a byproduct of pentose dehydration during the weak acid pretreatment of lignocellulose. In order to survive in the presence of furfural, yeast cells need not only to reduce furfural to the less toxic furan methanol, but also to protect themselves and repair any damage caused by the furfural. Since furfural tolerance in yeast require

SUBMITTER: Allen SA 

PROVIDER: S-EPMC2820483 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature