Minimization of biosynthetic costs in adaptive gene expression responses of yeast to environmental changes.

ABSTRACT: Yeast successfully adapts to an environmental stress by altering physiology and fine-tuning metabolism. This fine-tuning is achieved through regulation of both gene expression and protein activity, and it is shaped by various physiological requirements. Such requirements impose a sustained evolutionary pressure that ultimately selects a specific gene expression profile, generating a suitable adaptive response to each environmental change. Although some of the requirements are stress specific, it is likely that others are common to various situations. We hypothesize that an evolutionary pressure for minimizing biosynthetic costs might have left signatures in the physicochemical properties of proteins whose gene expression is fine-tuned during adaptive responses. To test this hypothesis we a

SUBMITTER: Vilaprinyo E 

PROVIDER: S-EPMC2820516 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature