Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements.

ABSTRACT: Control and coordination of eukaryotic gene expression rely on transcriptional and posttranscriptional regulatory networks. Evolutionary innovations and adaptations often require rapid changes of such networks. It has long been hypothesized that transposable elements (TE) might contribute to the rewiring of regulatory interactions. More recently it emerged that TEs might bring in ready-to-use transcription factor binding sites to create alterations to the promoters by which they were captured. A process where the gene regulatory architecture is of remarkable plasticity is sex determination. While the more downstream components of the sex determination cascades are evolutionary conserved, the master regulators can switch between groups of organisms even on the interspecies level or between

SUBMITTER: Herpin A 

PROVIDER: S-EPMC2820524 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature