Identification of novel glial genes by single-cell transcriptional profiling of Bergmann glial cells from mouse cerebellum.

ABSTRACT: Bergmann glial cells play critical roles in the structure and function of the cerebellum. During development, their radial processes serve as guides for migrating granule neurons and their terminal endfeet tile to form the glia limitans. As the cerebellum matures, Bergmann glia perform important roles in synaptic transmission and synapse maintenance, while continuing to serve as essential structural elements. Despite growing evidence of the diverse functions of Bergmann glia, the molecular mechanisms that mediate these functions have remained largely unknown. As a step toward identifying the molecular repertoire underlying Bergmann glial function, here we examine global gene expression in individual Bergmann glia from developing (P6) and mature (P30) mouse cerebellum. When we select for de

SUBMITTER: Koirala S 

PROVIDER: S-EPMC2820553 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature