A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.

ABSTRACT: Plants maintain stem cells in their meristems as a source for new undifferentiated cells throughout their life. Meristems are small groups of cells that provide the microenvironment that allows stem cells to prosper. Homeostasis of a stem cell domain within a growing meristem is achieved by signalling between stem cells and surrounding cells. We have here simulated the origin and maintenance of a defined stem cell domain at the tip of Arabidopsis shoot meristems, based on the assumption that meristems are self-organizing systems. The model comprises two coupled feedback regulated genetic systems that control stem cell behaviour. Using a minimal set of spatial parameters, the mathematical model allows to predict the generation, shape and size of the stem cell domain, and the underlying orga

SUBMITTER: Hohm T 

PROVIDER: S-EPMC2820555 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature