Pandora, a pathway and network discovery approach based on common biological evidence.

ABSTRACT:

Motivation

Many biological phenomena involve extensive interactions between many of the biological pathways present in cells. However, extraction of all the inherent biological pathways remains a major challenge in systems biology. With the advent of high-throughput functional genomic techniques, it is now possible to infer biological pathways and pathway organization in a systematic way by integrating disparate biological information.

Results

Here, we propose a novel integrated approach that uses network topology to predict biological pathways. We integrated four types of biological evidence (protein-protein interaction, genetic interaction, domain-domain interaction and semantic similarity of Gene Ontology terms) to generate a functionally associated network. This network

SUBMITTER: Zhang KX 

PROVIDER: S-EPMC2820679 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature