Ontology highlight
ABSTRACT:
SUBMITTER: Zhong L
PROVIDER: S-EPMC2821045 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Cell 20100101 2
SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes. Specifically, SIRT6 appears to function as a corepressor of the ...[more]