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Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.

ABSTRACT: Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.

SUBMITTER: Seyedsayamdost MR 

PROVIDER: S-EPMC2821070 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.

Seyedsayamdost Mohammad R MR   Chandler Josephine R JR   Blodgett Joshua A V JA   Lima Patricia S PS   Duerkop Breck A BA   Oinuma Ken-Ichi K   Greenberg E Peter EP   Clardy Jon J  

Organic letters 20100201 4

Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study. ...[more]

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