Association of circulating adhesion molecules with lung function. The CARDIA study.

ABSTRACT:

Background

Systemic inflammation has been associated with reduced lung function. Adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and P-selectin, figure importantly in initiating the inflammatory response. We studied the association between ICAM-1 and P-selectin concentrations and lung function in the Coronary Artery Risk Development in Young Adults study.

Methods

Spirometry testing was conducted at years 5, 10, and 20. ICAM-1 and P-selectin were assayed at year 15.

Results

Complete data were obtained from 2,455 participants. We first predicted year-20 lung function from year-15 ICAM-1 concentration data. After controlling for race, gender, height, age, physical activity, smoking status, alcohol intake, BMI, and asthma status, all taken at year 15,

SUBMITTER: Thyagarajan B 

PROVIDER: S-EPMC2821290 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature