Prediction of microRNAs affecting mRNA expression during retinal development.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) which have been shown to play an important role both in development and in maintenance of adult tissue. Conditional inactivation of miRNAs in the eye causes loss of visual function and progressive retinal degeneration. In addition to inhibiting translation, miRNAs can mediate degradation of targeted mRNAs. We have previously shown that candidate miRNAs affecting transcript levels in a tissue can be deduced from mRNA microarray expression profiles. The purpose of this study was to predict miRNAs which affect mRNA levels in developing and adult retinal tissue and to confirm their expression.

Results

Microarray expression data from ciliary epithelial retinal stem cells (CE-RSCs), developing and adult mouse

SUBMITTER: Arora A 

PROVIDER: S-EPMC2821300 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature