Electrocardiographic amplitudes: a new risk factor for sudden death in hypertrophic cardiomyopathy.

ABSTRACT:

Aims

Assessment of ECG-features as predictors of sudden death in adults with hypertrophic cardiomyopathy (HCM).

Methods and results

ECG-amplitude sums were measured in 44 normals, 34 athletes, a hospital-cohort of 87 HCM-patients, and 29 HCM-patients with sudden death or cardiac arrest (HCM-CA). HCM-patients with sudden death or cardiac arrest had substantially higher ECG-amplitudes than the HCM-cohort for limb-lead and 12-lead QRS-amplitude sums, and amplitude-duration products (P = 0.00003-P = 0.000002). Separation of HCM-CA from the HCM-cohort is obtained by limb-lead QRS-amplitude sum >or=7.7 mV (odds ratio 18.8, sensitivity 87%, negative predictive value (NPV) 94%, P < 0.0001), 12-lead amplitude-duration product >or=2.2 mV s (odds ratio 31.0, sensitivity 92%, NPV 97%, P

SUBMITTER: Ostman-Smith I 

PROVIDER: S-EPMC2821628 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature