Chemical phylogenetics of histone deacetylases.

ABSTRACT: The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived as nonselective. The synthesis and study of a focused library of cinnamic hydroxamates allowed the identification of, to our knowledge, the first nonselective HDAC inhibitor. These data will guide a more informed use of HDAC inhibitors as chemical probes and therapeutic agents.

SUBMITTER: Bradner JE 

PROVIDER: S-EPMC2822059 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature