Lynch syndrome among gynecologic oncology patients meeting Bethesda guidelines for screening.

ABSTRACT:

Objective

Lynch syndrome (LS) is characterized by a high lifetime incidence of colorectal cancer and gynecologic malignancies such as endometrial and ovarian cancer. Identification of LS families is important as it allows for heightened cancer screening which decreases colorectal cancer mortality. The original 1996 Bethesda guidelines included two gynecologic populations that should be further evaluated for LS: those with endometrial cancer before the age of 45 years and those with two LS-related cancers (i.e. synchronous endometrial and ovarian cancer). Our study aims to estimate the prevalence of LS in these two populations.

Methods

We utilized a diagnostic algorithm that included immunohistochemistry for mismatch repair protein expression followed by selective evaluation

SUBMITTER: Walsh CS 

PROVIDER: S-EPMC2822124 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature