Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts.

ABSTRACT:

Purpose

Mammography, the standard method of breast cancer screening, misses many cancers, especially in dense-breasted women. We compared the performance and diagnostic yield of mammography alone versus an automated whole breast ultrasound (AWBU) plus mammography in women with dense breasts and/or at elevated risk of breast cancer.

Methods

AWBU screening was tested in 4,419 women having routine mammography (

Trial registration

ClinicalTrials.gov Identifier: NCT00649337). Cancers occurring during the study and subsequent 1-year follow-up were evaluated. Sensitivity, specificity and positive predictive value (PPV) of biopsy recommendation for mammography alone, AWBU and mammography with AWBU were calculated.

Results

Breast cancer detection doubled from 23 to 46 i

SUBMITTER: Kelly KM 

PROVIDER: S-EPMC2822222 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature