Language laterality in autism spectrum disorder and typical controls: a functional, volumetric, and diffusion tensor MRI study.

ABSTRACT: Language and communication deficits are among the core features of autism spectrum disorder (ASD). Reduced or reversed asymmetry of language has been found in a number of disorders, including ASD. Studies of healthy adults have found an association between language laterality and anatomical measures but this has not been systematically investigated in ASD. The goal of this study was to examine differences in gray matter volume of perisylvian language regions, connections between language regions, and language abilities in individuals with typical left lateralized language compared to those with atypical (bilateral or right) asymmetry of language functions. Fourteen adolescent boys with ASD and 20 typically developing adolescent boys participated, including equal numbers of left- and right-

SUBMITTER: Knaus TA 

PROVIDER: S-EPMC2822339 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature