Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors.

ABSTRACT: Soft tissue tumors represent a group of neoplasia with different histologic and biological presentations varying from benign, locally confined to very aggressive and metastatic tumors. The molecular mechanisms responsible for such differences are still unknown. The understanding of these molecular alterations mechanism will be critical to discriminate patients who need systemic treatment from those that can be treated only locally and could also guide the development of new drugs' against this tumors. Using 102 tumor samples representing a large spectrum of these tumors, we performed expression profiling and defined differentially expression genes that are likely to be involved in tumors that are locally aggressive and in tumors with metastatic potential. We described a set of 12 genes (SN

SUBMITTER: Cunha IW 

PROVIDER: S-EPMC2822450 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature