Projection of gene-protein networks to the functional space of the proteome and its application to analysis of organism complexity.

ABSTRACT:

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We consider the problem of biological complexity via a projection of protein-coding genes of complex organisms onto the functional space of the proteome. The latter can be defined as a set of all functions committed by proteins of an organism. Alternative splicing (AS) allows an organism to generate diverse mature RNA transcripts from a single mRNA strand and thus it could be one of the key mechanisms of increasing of functional complexity of the organism's proteome and a driving force of biological evolution. Thus, the projection of transcription units (TU) and alternative splice-variant (SV) forms onto proteome functional space could generate new types of relational networks (e.g. SV-protein function networks, SFN) and lead to discoveries of novel evolutionarily conser

SUBMITTER: Kanapin AA 

PROVIDER: S-EPMC2822532 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature