SERPING1 polymorphisms in polypoidal choroidal vasculopathy.

ABSTRACT:

Purpose

To investigate whether common genetic variants in the complement component 1 inhibitor gene (serpin peptidase inhibitor, clade G, member 1, SERPING1) are associated with polypoidal choroidal vasculopathy (PCV) in a Chinese Han population.

Methods

DNA samples were obtained from 118 PCV patients and 115 healthy subjects. Data derived from the HapMap project were used to select tag single nucleotide polymorphisms (SNPs) across the extended SERPING1 region. A previously reported age-related macular degeneration-related risk factor (rs2511989) was forcibly included. Genotyping of each tag SNP was performed by PCR restriction fragment length polymorphism and direct DNA sequencing techniques.

Results

Four SNPs for SERPING1, rs2509897, rs1005510, rs11603020, and rs251

SUBMITTER: Li M 

PROVIDER: S-EPMC2822549 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature