Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information.

ABSTRACT:

Background

The genetic contributions to human common disorders and mouse genetic models of disease are complex and often overlapping. In common human diseases, unlike classical Mendelian disorders, genetic factors generally have small effect sizes, are multifactorial, and are highly pleiotropic. Likewise, mouse genetic models of disease often have pleiotropic and overlapping phenotypes. Moreover, phenotypic descriptions in the literature in both human and mouse are often poorly characterized and difficult to compare directly.

Methods

In this report, human genetic association results from the literature are summarized with regard to replication, disease phenotype, and gene specific results; and organized in the context of a systematic disease ontology. Similarly summarized mo

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2822734 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature