Identification of interacting transcription factors regulating tissue gene expression in human.

ABSTRACT:

Background

Tissue gene expression is generally regulated by multiple transcription factors (TFs). A major first step toward understanding how tissues achieve their specificity is to identify, at the genome scale, interacting TFs regulating gene expression in different tissues. Despite previous discoveries, the mechanisms that control tissue gene expression are not fully understood.

Results

We have integrated a function conservation approach, which is based on evolutionary conservation of biological function, and genes with highest expression level in human tissues to predict TF pairs controlling tissue gene expression. To this end, we have identified 2549 TF pairs associated with a certain tissue. To find interacting TFs controlling tissue gene expression in a broad spatial

SUBMITTER: Hu Z 

PROVIDER: S-EPMC2822763 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature