Genome-wide computational prediction of tandem gene arrays: application in yeasts.

ABSTRACT:

Background

This paper describes an efficient in silico method for detecting tandem gene arrays (TGAs) in fully sequenced and compact genomes such as those of prokaryotes or unicellular eukaryotes. The originality of this method lies in the search of protein sequence similarities in the vicinity of each coding sequence, which allows the prediction of tandem duplicated gene copies independently of their functionality.

Results

Applied to nine hemiascomycete yeast genomes, this method predicts that 2% of the genes are involved in TGAs and gene relics are present in 11% of TGAs. The frequency of TGAs with degenerated gene copies means that a significant fraction of tandem duplicated genes follows the birth-and-death model of evolution. A comparison of sequence identity distributi

SUBMITTER: Despons L 

PROVIDER: S-EPMC2822764 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature