Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans.

ABSTRACT:

Background

Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain.

Results

We have used array comparative genomic hybridization (aCGH) to detect copy number variation in the genomes of 12 natural isolates of Caenorhabditis elegans. Deletions relative to the canonical N2 strain are more common in these isolates than duplications, and indels are enriched in multigene families on the autosome arms. Among the strains in our study, the Hawaiian and Madeiran strains (CB4856 and JU258) carry the largest number of deletions, followed by the Vancouver strain (KR314). Overall we detected 510 different d

SUBMITTER: Maydan JS 

PROVIDER: S-EPMC2822765 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature