A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

ABSTRACT:

Rationale

Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. The pleiotropic cytokine tumor necrosis factor-alpha is essential to control tuberculosis infection, and various tumor necrosis factor family members and their respective receptors may contribute to tuberculosis risk.

Objectives

To investigate four functionally relevant polymorphisms in the tumor necrosis factor receptor 2-encoding gene, tumor necrosis factor receptor superfamily member 1B, for association with tuberculosis susceptibility.

Methods

Genotyping of four polymorphisms was performed in independent populations from South Africa (429 cases and 482 control subjects) and Ghana (640 cases and 1,158 control subjec

SUBMITTER: Moller M 

PROVIDER: S-EPMC2822974 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature