WD repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization.

ABSTRACT: Myosin II disassembly in Dictyostelium discoideum is regulated by three structurally related myosin heavy chain kinases (myosin II heavy chain kinase A [MHCK-A], -B, and -C). We show that the WD repeat domain of MHCK-C is unique in that it mediates both substrate targeting and subcellular localization, revealing a target for regulation that is distinct from those of the other MHCKs.

SUBMITTER: Franklin A 

PROVIDER: S-EPMC2823011 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature