The protein-protein interface evolution acts in a similar way to antibody affinity maturation.

ABSTRACT: Understanding the evolutionary mechanism that acts at the interfaces of protein-protein complexes is a fundamental issue with high interest for delineating the macromolecular complexes and networks responsible for regulation and complexity in biological systems. To investigate whether the evolution of protein-protein interface acts in a similar way as antibody affinity maturation, we incorporated evolutionary information derived from antibody affinity maturation with common simulation techniques to evaluate prediction success rates of the computational method in affinity improvement in four different systems: antibody-receptor, antibody-peptide, receptor-membrane ligand, and receptor-soluble ligand. It was interesting to find that the same evolutionary information could improve the predict

SUBMITTER: Li B 

PROVIDER: S-EPMC2823529 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature