Ginkgo biloba for prevention of dementia: a randomized controlled trial.

ABSTRACT:

Context

Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking.

Objective

To determine effectiveness of G. biloba vs placebo in reducing the incidence of all-cause dementia and Alzheimer disease (AD) in elderly individuals with normal cognition and those with mild cognitive impairment (MCI).

Design, setting, and participants

Randomized, double-blind, placebo-controlled clinical trial conducted in 5 academic medical centers in the United States between 2000 and 2008 with a median follow-up of 6.1 years. Three thousand sixty-nine community volunteers aged 75 years or older with normal cognition (n = 2587) or MCI (n = 482) at study entry

SUBMITTER: DeKosky ST 

PROVIDER: S-EPMC2823569 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature