Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder.

ABSTRACT:

Background

Comorbidity of psychiatric and substance use disorders represents a significant complication in the clinical course of both disorders. Bipolar Disorder (BD) is a psychiatric disorder characterized by severe mood swings, ranging from mania to depression, and up to a 70% rate of comorbid Tobacco Use Disorder (TUD). We found epidemiological evidence consistent with a common underlying etiology for BD and TUD, as well as evidence of both genetic and environmental influences on BD and TUD. Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD.

Methods

Using meta-analysis, we compared TUD rates for BD patients and the general population. We identified candidate genes showing sta

SUBMITTER: McEachin RC 

PROVIDER: S-EPMC2823619 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature