Angiotensin II receptor expression and relation to Helicobacter pylori-infection in the stomach of the Mongolian gerbil.

ABSTRACT:

Background

The role of the renin-angiotensin system in gastric physiology and disease has as yet been sparsely explored. The first aim of the study was to investigate the baseline presence and location of angiotensin II receptors (AT1R and AT2R) in the stomach of the Mongolian gerbil. A second aim was to elucidate whether the presence of H. pylori infection is associated with changes in the expression of these receptors.

Methods

H. pylori-negative and H. pylori-infected (strain SS1 or TN2GF4) male Mongolian gerbils were investigated. The stomachs were examined at six or 12 months after inoculation by the use of immunohistochemistry, western blot and microscopic morphometry.

Results

AT1R and AT2R were located in a variety of cells in the gerbil gastric wall, including

SUBMITTER: Hallersund P 

PROVIDER: S-EPMC2823647 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature