IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.

ABSTRACT:

Background

Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately.

Methods

We used an ex vivo culture model and measured gene expression changes after IGF-I stimulation with cDNA microarrays. In vitro data were correlated with in vivo findings by comparing the results with published expression datasets on human cancer biopsies.

Results

Upon stimulation with IGF-I, breast cancer cells and stromal fibroblasts show some common and other distinct response patterns. Among the up-regulated genes in the stromal fibroblasts we observed a significant enrichment in proli

SUBMITTER: Rajski M 

PROVIDER: S-EPMC2823652 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature