Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa.

ABSTRACT:

Background

Blood coagulation is a complex network of biochemical reactions, which is peculiar in that it is time- and space-dependent, and has to function in the presence of rapid flow. Recent experimental reports suggest that flow plays a significant role in its regulation. The objective of this study was to use systems biology techniques to investigate this regulation and to identify mechanisms creating a flow-dependent switch in the coagulation onset.

Results

Using a detailed mechanism-driven model of tissue factor (TF)-initiated thrombus formation in a two-dimensional channel we demonstrate that blood flow can regulate clotting onset in the model in a threshold-like manner, in agreement with existing experimental evidence. Sensitivity analysis reveals that this is achiev

SUBMITTER: Shibeko AM 

PROVIDER: S-EPMC2823678 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature