Simple sequence repeats in Helicobacter canadensis and their role in phase variable expression and C-terminal sequence switching.

ABSTRACT:

Background

Helicobacter canadensis is an emerging human pathogen and zoonotic agent. The genome of H. canadensis was sequenced previously and determined to contain 29 annotated coding regions associated with homopolymeric tracts.

Results

Twenty-one of the repeat-associated coding regions were determined to be potentially transcriptionally or translationally phase variable. In each case the homopolymeric tract was within the predicted promoter region or at the 5' end of the coding region, respectively. However, eight coding sequences were identified with simple sequence repeats toward the 3' end of the open reading frame. In these cases, the repeat tract would be too far into the coding region to be mediating translational phase variation. All of the 29 coding region-associat

SUBMITTER: Snyder LA 

PROVIDER: S-EPMC2823697 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature