The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history.

ABSTRACT:

Background

The emergence of agriculture about 10,000 years ago marks a dramatic change in human evolutionary history. The diet shift in agriculture societies might have a great impact on the genetic makeup of Neolithic human populations. The regionally restricted enrichment of the class I alcohol dehydrogenase sequence polymorphism (ADH1BArg47His) in southern China and the adjacent areas suggests Darwinian positive selection on this genetic locus during Neolithic time though the driving force is yet to be disclosed.

Results

We studied a total of 38 populations (2,275 individuals) including Han Chinese, Tibetan and other ethnic populations across China. The geographic distribution of the ADH1B*47His allele in these populations indicates a clear east-to-west cline, and it is d

SUBMITTER: Peng Y 

PROVIDER: S-EPMC2823730 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature