Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships.

ABSTRACT:

Background

Nonribosomal peptide synthetases (NRPSs) are multimodular enzymes, found in fungi and bacteria, which biosynthesize peptides without the aid of ribosomes. Although their metabolite products have been the subject of intense investigation due to their life-saving roles as medicinals and injurious roles as mycotoxins and virulence factors, little is known of the phylogenetic relationships of the corresponding NRPSs or whether they can be ranked into subgroups of common function. We identified genes (NPS) encoding NRPS and NRPS-like proteins in 38 fungal genomes and undertook phylogenomic analyses in order to identify fungal NRPS subfamilies, assess taxonomic distribution, evaluate levels of conservation across subfamilies, and address mechanisms of evolution of multimodular

SUBMITTER: Bushley KE 

PROVIDER: S-EPMC2823734 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature