HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

ABSTRACT: Metastasis leads to the death of most cancer patients, and basal breast cancer is the most aggressive breast tumor type. Metastasis involves a complex cell migration process dependent on cytoskeletal remodeling such that targeting such remodeling in tumor cells could be clinically beneficial. Here we show that Hormonally Up-regulated Neu-associated Kinase (HUNK) is dramatically down-regulated in tumor samples and cell lines derived from basal breast cancers. Reconstitution of HUNK expression in basal breast cancer cell lines blocked actin polymerization and reduced cell motility, resulting in decreased metastases in two in vivo murine cancer models. Mechanistically, HUNK overexpression sustained the constitutive phosphorylation and inactivation of cofilin-1 (CFL-1), thereby blocking the in

SUBMITTER: Quintela-Fandino M 

PROVIDER: S-EPMC2823890 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature